feuA [2017-02-27 15:02:04]

ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with YusV as ATPase

locus: BSU01630

pI: 8.00

mw: 34.00 kDa

protein length: 317 aa

gene length: 951 bp

function: acquisition of iron

product: ABC transporter for the siderophores Fe-enterobactin
and Fe-bacillibactin (binding protein)

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|Btr regulon], [SW|Fur regulon], [SW|CitB regulon] (putative)

Gene

Coordinates on the chromosome (coding sequence): 182,370 -> 183,323

The protein

Protein family

• Fe/B12 periplasmic-binding domain (according to Swiss-Prot)

[SW|Domains]

• Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).

Modification

• FeuA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure [Pubmed|22303020]

Structure

• [PDB|2PHZ], [PDB|2WI8], [PDB|2WHY] (complex with ferri-bacillibactin), [PDB|2XUZ] (complex with ferri-enterobactin), [PDB|2XV1] (complex with ferric mecam)

[SW|Localization]

• associated to the membrane (lipoprotein) [Pubmed|22303020]
• extracellular (signal peptide) [Pubmed|18957862]

Expression and Regulation: [[this]]

References

• 20086155,19746494,19673474,14563870,16672620,10092453,16889643,17725565,12354229,18957862,18763711,22303020,10468622