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feuA [2017-02-27 15:02:04]
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feuA [2017-02-27 15:02:04]

ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with YusV as ATPase
locus
BSU01630
pI
8.00
mw
34.00 kDa
protein length
317 aa Sequence Blast
gene length
951 bp Sequence Blast
function
acquisition of iron
product
ABC transporter for the siderophores Fe-enterobactin
and Fe-bacillibactin (binding protein)
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|Btr regulon], [SW|Fur regulon], [SW|CitB regulon] (putative)
  • Gene

    Coordinates on the chromosome (coding sequence)
    182,370 -> 183,323

    The protein

    Protein family

  • Fe/B12 periplasmic-binding domain (according to Swiss-Prot)
  • [SW|Domains]

  • Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).
  • Modification

  • FeuA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure [Pubmed|22303020]
  • Structure

  • [PDB|2PHZ], [PDB|2WI8], [PDB|2WHY] (complex with ferri-bacillibactin), [PDB|2XUZ] (complex with ferri-enterobactin), [PDB|2XV1] (complex with ferric mecam)
  • [SW|Localization]

  • associated to the membrane (lipoprotein) [Pubmed|22303020]
  • extracellular (signal peptide) [Pubmed|18957862]
  • Expression and Regulation
    [[this]]

    References

  • 20086155,19746494,19673474,14563870,16672620,10092453,16889643,17725565,12354229,18957862,18763711,22303020,10468622